Serum lipid profile in patients with ischaemic stroke the - correlation between them
Keywords:
lipid profile, ischemic stroke, Serum lipid profileAbstract
Objective: The purpose of the study was to study the serum lipid profile in patients with ischaemic stroke and to determine significant correlation between them.
Materials and Methods:
Study design : Cross sectional study of one year.
Study Centre : Patients admitted in the indoor wards of Medicine Department of Govt Medical College and Rajindra Hospital , Patiala.
Method of Collection of Data : A minimum of 50 patients aged >35yrs, both male and females who were diagnosed to have ischaemic cerebrovascular disease and who matched the inclusion and exclusion criteria were selected.
Results:
Mean age in this study was 59.48 years. Among the study population, 24 (48%) were males and 26 (52%) were females. Most of ischaemic stroke patients (90%) fell in the 40-79 years age group and Dyslipidemia was observed in 78 % of ischaemic stroke patients enrolled in this study . Highest prevalence of ischaemic stroke is found in the 60-69 years age group. Among ischaemic stroke patients with dyslipidemia enrolled in this study the frequency of lipid profile derangements were as follows :
-Deranged HDL (males <35.3mg/dL, female <42mg/dL) in 61.5 % of
Ischemic stroke patients
-Deranged total cholesterol (>200 mg/dl) in 46.2 % of ischaemic stroke patients.
- Deranged Triglycerides in (>161mg/dL) in 25.6 % of ischaemic stroke patients.
-Deranged LDL in (>153mg/dL) in 23.1 % of ischaemic stroke patients.
-Deranged VLVL (>40mg/dL) in 7.7 % of ischaemic stroke patients.
Conclusion: Hence ,we could conclude from our study that dyslipidemia is associated with ischemic stroke. This also underlines the importance of identifying the risk factors of ischaemic stroke as early identification and modification of risk factors may help reduce the occurrence of stroke. However, more data and studies are required especially in Indian context to accurately define the relationship of dyslipidemia with ischmic stroke.
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References
Harrison’s principles of internal medicine. 18th ed. New York, NY: McGraw-Hill Professional; 2011:3270.
Strong K, Mathers C, Bonita R. Preventing stroke: saving lives around the world. The Lancet Neurology. 2007 Feb 1;6(2):182-7.
Adam RJ, Mckie VC, Brambilla D. Stroke prevention trail in sickle cell anemia. New Eng J Med. 1998;19:110–29.
World Health Organization (WHO). The top 10 causes of death. World Health Organization. 2016. http://www.who.int/mediacentre/factsheets /fs310/en
Miniño AM, Xu J, Kochanek KD. Deat/ hs: preliminary data for 2008. National vital statistics reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. 2010 Dec 1;59(2):1-52
Young DS:Effects of drugs on clinical laboratory tests.Third edition.1990;6:19-25.
Roeschlau P, Bernt E, Gruber, W.A: Enzymatic determination of total cholesterol in serum. Clin Chem.Clin Biochem.1974;12:226.
Barr DP, Russ EM, Eder HA. Protein-lipid relationships in human plasma. Am J Med.1951;11(4):480–93.
Friedewald WT, Levy RJ, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem.1972;18(6):499-502.
Allain CC, Poon LS, Chan CS, Richmond W, FuPC. Enzymatic determination of total serum cholesterol. Clin Chem 1974;20(4):470-5
McGowan MW, Artiss JD, Strandbergh DR, Zak B. A peroxidisecoupled method for the colorimetric determination of serum triglycerides . Clin Chem.1983;29(3):538-42.
Al-Rajeh S, Larbi E, al-Freihi H, Ahmed K, Muhana F, Bademosi O. A clinical study of stroke. East Afr Med J. 1989; 66(3):183-91.
Al-Eithan MH, Amin M, Robert AA. The effect of hemiplegia/ hemiparesis, diabetes mellitus, and hypertension on hospital length of stay after stroke. Neurosciences Journal. 2011 Jul 1;16(3):253-6.
Al-Jadid MS, Robert AA. Determinants of length of stay in an inpatient stroke rehabilitation unit in Saudi Arabia. Saudi Med J. 2010 Feb 1;31(2):189-92.
Haberman S, Capildeo R, Rose FC. Sex differences in the incidence of cerebrovascular disease. Journal of Epidemiology & Community Health. 1981 Mar 1;35(1):45-50.
Yaqub BA, Shamena AR, Kolawole TM, Patel PJ. Cerebrovascular disease in Saudi Arabia. Stroke. 1991 Sep;22(9):1173-6.
Siddeswari R, Manohar S, Sudarsi B, Suryanarayana B, Kumar SP, Abhilash T. Pattern of dyslipidemia in ischemic stroke. Journal of Medical & Allied Sciences. 2015;5(2):26
Singh JP,Nagvanshi S. Prospective cross sectional study of incidence and correlation of dyslipidemia in predicting outcome of patients diagnosed with cerebrovascular accident. International Journal of Contemporary Medical Research 2017 ;4(6):1244-5.
Vijeth SB, Mangasuli V, Amrutha AM, Bhoovanchandra N, Sidenur B. A Cross Sectional Study of Lipid Profile in Non-Diabetics with Stroke in Urban Chitradurga. International Journal of Medicine and Medical Research. 2021;7(1):68-73.
Ali I, Abuissa M, Alawneh A, Subeh O, Abu Sneineh A, Mousa S, Deeb I, Rayyan H. The prevalence of dyslipidemia and hyperglycemia among stroke patients: preliminary findings. Stroke research and treatment. 2019 Oct 30;2019
Habibi-koolaee M, Shahmoradi L, Kalhori SR, Ghannadan H, Hosseini A, Younesi E. Lipid profile and the risk of stroke: A study from North of Iran. J Res Med Dent Sci. 2018 Feb 1;6(1):343-49.
Mythili S. A Study of Lipid Profile in Nondiabetics with Stroke (Doctoral dissertation, Kilpauk Medical College, Chennai)