Antibody Screening and Identification among Voluntary Blood Donors at RBTC of North India
Keywords:
Autoantibodies, alloantibodies, irregular red cell antibodiesAbstract
Introduction; The purpose of antibody screening is to detect red cell antibodies other than anti A & anti B in the human serum. There are called unexpected antibodies. These are found only in 0.3-2% of general population. The development of these antibodies can complicate transfusion therapy and result in difficulties in cross match of blood. This study is aimed at assessing the frequency and type of unexpected red cell antibodies in the voluntary blood donors. Methods: The results of 17864 Antibody screening tests carried on voluntary blood donors from Jan. 2017 to Dec. 2017 were complied and analysed. Results: A total of 17864 samples were screened for the presence of unexpected antibodies. Antibody screening was positive in 7 donors (0.03%). (Table-1 Fig.-2) In the serum of 4 (57.1%) donors autoantibodies were identified, 2 (28.5%) revealed auto antibodies, while 1 (14.2%) had non-specific antibodies. The most common alloantibody identified being Anti E (50%). (Fig.-1) Conclusion: Since clinically significant antibodies are detected in voluntary blood donors, antibody screening and if required identification is the need of hour for provision of safe blood transfusion.
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