Bone metastasis from endometrioid ovarian carcinoma: a case study and literature review
Keywords:
varian epithelial malignancy, post menopausal, bony metastasis, serum CA 125 levelsAbstract
AbstractOvarian epithelial malignancy rarely metastasize to the skeletal system. They usually spread by direct extension , transcoelemic spread and by lymphatic channel. Hematogenous spread is rare and late occurance. Metastasis to bone from these tumours is rare. (0.1- 0.12%) and is reported in a few series. A 75 year old post menopausal lady presented in surgery department with chief complaints of swelling and pain over left thigh since 2 months. Swelling appeared 5 months back , it was drained at that time, but recurred 1 month back. Grossly we received skin covered biopsy, partly solid and partly cystic in multiple pieces measuring 12x11.5x 2.5 cm. external surface of skin was ulcerated and cut surface showed necrotic areas. Two bony pieces were received separately. Section from bony pieces showed deposits of tumour cells amongst normal bony trabeculae. Diagnosis of bony metastasis from unknown primary was made and clinicians were informed to search for primary in ovary, breast, GIT etc. serum CA 125 levels were increased to 230 U/ml.
Downloads
References
J. Sehouli, J. Olschewski, V. Schotters, C. Fotopoulou & K. Pietzner. Prognostic role of early versus late onset of bone metastasis in patients with carcinoma of the ovary, peritoneum and fallopian tube.Annals of Oncology, Volume 24, Issue 12, 3024 – 8
Zhang C, Guo X, Peltzer K, Ma W, Qi L, Zhang Y, Han X, Baklaushev VP, Yao Y, Wang G, Chekhonin VP, Wang X, Ma Y. The prevalence, associated factors for bone metastases development and prognosis in newly diagnosed ovarian cancer: a large population based real-world study. J Cancer. 2019 Jun 2;10(14):3133-9.
Hong L, Cristiano L, Peters E, Ioffe Y. Detection of bone metastases in uterine cancer: How common are they and should PET/CT be the standard for diagnosis? Gynecol Oncol Rep. 2021 Jan 8;35:100698.
N. Baize, A. Mahamat, E. Benizri, M.C. Saint-Paul, N. Mounier.Bone metastasis from endometrioid ovarian carcinoma: a case study and literature review.Eur. J. Gynaec. Oncol.- 326-8.
