Study of Efficacy and Safety of Intralesional MMR in Treatment of Warts
Keywords:
Warts, Mucocutaneous, Human Papilloma Virus, Recalcitrant, ImmunotherapyAbstract
Wart is a mucocutaneous disease developing as a result of proliferation of skin or mucosal cells infected with human papilloma virus (HPV). Management of periungual, palmer and plantar warts is quite difficult with traditional methods like TCA, electrosurgery & cryotherpy. Intralesional immunotherapy clears not only the local warts but also distant warts unlike traditional wart therapies. In our study to evaluate the efficacy and safety of intralesional MMR vaccine in treatment of warts, we included 50 patients with single or multiple reclcirant or non reclcirant periungual, palmar and plantar warts with 20 patients as controls who were injected with normal saline. MMR vaccine was injected in a single lesion or largest wart in case of multiple warts at 2 weekly intervals until complete clearance. Complete response was achieved in 86.6% of patients with periungual, palmer and plantar warts and 20% in control group. Pain during injection was found in 85.7% patients. Intralesional immunotherapy by MMR vaccine in a promising effective and safe treatment modality for warts.
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References
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