Dengue biting again : A five year retrospective study in a tertiary care hospital
Keywords:
Dengue Fever, Arbovirus, Hemorrhage, Shock, ELISAAbstract
Dengue fever is caused by an arbovirus worldwide, especially in the tropical and sub-tropical regions. Its clinical manifestations range from mild fever to a severe disease characterized by hemorrhage and shock. This is transmitted to humans by day-biting Aedes aegypti and Aedes albopictus mosquitoes. Methods: A total of 18637cases were detected in last five years (2014-2018). 5 ml blood sample was collected from the suspected cases of Dengue, which were tested by NS1 Antigen detection by NS1Ag ELISA and for IgM antibody by IgM MAC ELISA depending upon the duration of fever. Results: Out 0f 18637, 10447 cases were positive for Dengue infection. The infection was more in males as compare to females and was more common in the age group of 21-40 years (42.2%). The disease is more prevalent in urban areas (69%) as compare to rural areas(31%). It was revealed from the present study that the trend of dengue infection is keep on increasing with each successive year from 2014 to 2018. Conclusion: Dengue affects humans of all age-groups and causes high moratlity. Thus, a rapid and accurate dengue diagnosis is of paramount importance for effective control of dengue outbreaks.
Downloads
References
Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ et al Dengue: a continuing global threat. Nat Rev Microbiol. 2010 Dec;8 (12 Suppl):S7-16.
Duane J. GublerDengue and Dengue Haemorrhagic FeverClin Microbiol Rev 1998 Jul; 11(3): 480–496.
Dinesh Subedi, Andrew W. Taylor-Robinson. Laboratory Diagnosis of Dengue Infection: Current Techniques and Future Strategies. Open Journal of Clinical Diagnostics, 2014, 4, 63-70
Jawetz,melnick and Adelberg's medical MicrobiologyMc Grew Hill 22 Edition pg No 441-442.
Dengue and severe dengue fact sheet update April 2017. WHO
Gupta E, Ballani N. Current perspectives on the spread of dengue in India. Infect Drug Resist. 2014 Dec 11;7:337-42.
Guzman MG, et al. Epidemiologic studies on Dengue in Santiago de Cuba, 1997. Am. J. Epidemiol. 2000;152:793–799.
Guzman MG, et al. Effect of age on outcome of secondary dengue 2 infections. Int. J. Infect. Dis. 2002;6:118–124.
Chareonsirisuthigul T, Kalayanarooj S, Ubol S. Dengue virus (DENV) antibody-dependent enhancement of infection upregulates the production of anti-inflammatory cytokines, but suppresses anti-DENV free radical and proinflammatory cytokine production, in THP-1 cells. J. Gen. Virol. 2007;88:365–375.
Shamimul Hasan, Sami Faisal Jamdar,Munther AlalowiandSadun Mohammad Al Ageel Al Beaiji. Dengue virus: A global human threat: Review of literature J Int Soc Prev Community Dent. 2016 Jan-Feb; 6(1): 1–6.
Dengue Guidelines for Diagnosis, Treatment, Prevention And Control Treatment, Prevention And Control Treatment, Prevention And Control. WHO; Geneva, Switzerland: 2009
Ilkal MA, Dhanda V, Hassan MM, Mavale M, Mahadev PV, Shetty PS, et al. Entomological Investigations During Outbreaks of Dengue Fever in Certain Villages in Maharashtra State. Indian Journal Medical Research 1991;93:174–8. 22. Keating J. An Investigation into the Cyclical Incidence of Dengue Fever. Social Science and Medicine 2001;53:1587–97.
Dutta P, Mahanta J. Potential Vectors of Dengue and the Profile of Dengue in the North eastern Region of India: An Epidemiological Perspective. WHO Dengue Bulletin 2006;30:234–42.
Broor S, Dar L, Sengupta S, Chakaraborty M, Wali JP, Biswas A, et al. Recent dengue epidemic in Delhi, India. In: Saluzzo JF, Dodet B, editors. Factors in the Emergence of Arboviruses Diseases. Paris: Elsevier; 1997. pp. 123–7.
Dar L, Broor S, Sengupta S, Xess I, Seth P. The first major outbreak of dengue haemorrhagic fever inDelhi, India. Emerg Infect Dis. 1999;5:589–90.
Gupta E, Dar L, Narang P, Srivastava VK, Broor S. Serodiagnosis of dengue during an outbreak at a tertiary care hospital in Delhi. Indian J Med Res. 2005;121:36–8.
Kaur H, Prabhakar H, Mathew P, Marshalla R, Arya M. Dengue haemorrhagic fever outbreak in October-November 1996 in Ludhiana, Panjab, India. Indian J Med Res. 1997;106:1–3. the other authors in Northern part of India [9,10, 25,26,27,28,29] medical MicrobiologyMc Grew Hill 22 Edition pg No 441-442. nd 5. Dengue and severe dengue fact sheet update April 2017. WHO
Chakravarti A, Kumaria R, Kar P, Batra VV, Verma V. Improved detection of dengue virus serotypes from serum samples – evaluation of single-tube multiplex RT-PCR with cell culture. Dengue Bulletin 2006; 30: 133-40.
Neeraja M, Lakshmi V, Teja VD, Umabala P, Subbalakshmi MV. Serodiagnosis of dengue virus infection in patients presenting to a tertiary care hospital. Indian J Med Microbiol 2006; 24(4): 280-82.
Agarwal R, Kapoor S, Nagar R, Mishra A, Tandon R, Mathur A, et al. A clinical study of the patients with dengue haemorrhagic fever during the epidemic of 1996 at Lucknow, India. Southeast Asian J Trop Med Public Health 1999; 30(4): 735-40.
