Acute Myeloid Leukemia with Basophilia with t(6;9) (p23;q34) – A Rare Subtype of AML
Keywords:
Acute Myeloid Leukaemia, Basophilia, t (6;9) (p23;q34)Abstract
Acute Myeloid Leukemia (AML) with the translocation t(6;9) (p23;q34), involving breaks at band 23 of the short arm of chromosome 6 and band 34 of the long arm of chromosome 9, is a rare subtype, representing 0.5% to 4% of AML cases.1
A 50-year-old male presented with a gradual onset of fever and a cough with expectoration lasting for one month, followed by episodes of hemoptysis and associated generalized weakness. He also reported history of blood transfusions and recurrent infections in the past. The persistent symptoms, along with the patient's medical history, raised concerns for an underlying chronic infection or hematological disorders.
Laboratory investigations - Hemoglobin levels : 8.7 g/dl
Bone marrow findings:-
Cellularity- Moderately cellular
Reaction- Mild megaloblastic
NE:E ratio- 98:2
Erythroid series: Markedly diminished with mild megaloblastic maturation and features of dyserythropoiesis seen.
Myeloid series: Cellularity of marrow is mainly due to medium sized Blasts(70%) showing basophilic cytoplasm with 1-4 conspicuous nucleoli. Scattered cells are seen covered with basophilic granules. Basophilic precursors (17%) are increased in number. Rest of the myeloid series is markedly diminished.
Rare Megakaryocyte seen.
Impression:- Acute Myeloid Leukemia (AML) with Basophilia.
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References
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