Rare Adrenal Incidentaloma: Ganglioneuroma
Keywords:
ganglioneuromaAbstract
Adrenal ganglioneuromas (AGNs) are rare, benign, well-differentiated tumors of neural crest origin. They are usually hormonally non-functional and asymptomatic, frequently discovered incidentally during imaging for unrelated concerns. We present the case of a 19-year-old female who exhibited vague gastrointestinal and autonomic symptoms. Imaging revealed a right adrenal mass suggestive of malignancy. However, hormonal evaluation was unremarkable. Surgical excision was performed, and histopathology confirmed the diagnosis of adrenal ganglioneuroma. This case underscores the diagnostic challenge of such rare adrenal incidentalomas and highlights the importance of multimodal imaging and histopathology in guiding management.
Downloads
References
Bovio S, Cataldi A, Reimondo G, et al. Prevalence of adrenal incidentaloma in a contemporary computerized tomography series. J Endocrinol Invest. 2006;29(4):298-302.
Geoerger B, Hero B, Harms D, et al. Metabolic activity and clinical features of primary ganglioneuromas. Cancer. 2001;91 (10): 1905-1913.
Linos D, Stylopoulos N, Vlahos N, et al. Adrenal ganglioneuromas: incidental findings and clinical significance. World J Surg. 1997;21 (8):850-854.
Yildiz L, Aiwa T, Vardar E, Yilmaz N. Adrenal ganglioneuroma: a rare tumor. Endocr J. 2003; 50(5):613-616.
Ichikawa T, Ohtomo K, Araki T, et al. Ganglioneuroma: computed tomography and magnetic resonance features. Br J Radiol. 1996;69(827):114-121.
Hayes FA, Green AA, Rao BN. Clinical manifestations of ganglioneuroma. Cancer. 1989; 63(6): 1211-1214.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation.Radiographics.2002;22(4):911-934.
Kinoshita Y, Kurata A, Kinoshita F, et al. MR imaging of adrenal ganglioneuroma: report of two cases. Radiat Med. 1999;17(6):441-444.
Gagner M, Lacroix A, Bolte E. Laparoscopic adrenalectomy in Cushing's syndrome and pheochromocytoma. N Engl J Med. 1992;327 (14):1033.
